Secondary antibodies where bovine is the host species. Secondary antibodies must be raised against the host species of the primary antibody. Includes different antigens, classifications, conjugations, and isotypes.
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An agonist of the adenosine A2A receptor and an inhibitor of ENT1 (Kis 4 39 and 3 47 UM for the human receptor and guinea pig transporter respectively) decreases adenosine uptake by 80 in PC12 cells at 61 UM and increases brain levels of adenosine in a transgenic mouse model of Huntingtons disease at 20 mg/kg rescues motor performance and increases survival in a transgenic mouse model of Huntingtons disease at 0 11 mg/kg
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An ABHD12 inhibitor (IC50 11 nM) inhibits ABHD-dependent hydrolysis of lyso-PS in mouse brain membrane lysates (IC50 2.8 nM) and human THP-1 cells increases levels of CCL3 CCL4 TNF-a and IL-1B in M1-polarized THP-1 macrophages increases levels of 1-stearoyl-2-hydroxy-sn-glycero-3-PS 1-arachidonoyl-2-hydroxy-sn-glycero-3-PS 1-docosanoyl-2-hydroxy-sn-glycero-3-PS 1-stearoyl-2-arachidonoyl-sn-glycero-3-PS and 1-oleoyl-2-arachidonoyl-sn-glycero-3-PS in mouse brain at 30 mg/kg per day for four weeks increases levels of CCL2 CCL3 and CCL5 in BALF and decreases survival in a mouse model of infection with LCMV clone 13 at 30 mg/kg
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A σ1 receptor antagonist (Ki 17 nM) selective for σ1 receptors over σ2 receptors (Ki 9300 nM) as well as a panel of 170 additional receptors at 1 UM reduces capsaicin-induced mechanical allodynia formalin-induced licking and biting behavior and partial sciatic nerve-ligation induced thermal hyperalgesia in mice (ED50s 26.3 43.7 and 18.8 mg/kg respectively) enhances fentanyl- or loperamide-induced analgesia without affecting gastrointestinal transit in mice
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A BAP1 inhibitor inhibits BAP1 deubiquitinase activity in a cell-free assay 25 UM-1.5 mM cytotoxic against a panel of eight colon cancer cell lines (IC50s 4.48-7.52 UM) reduces tumor volume in an HCT116 colon cancer mouse xenograft model at 10 and 30 mg/kg
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